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Diagnosis Safe Moderate Evidence

ClinGen search dosage sensitivity

by Harvard MIMS Lab (ToolUniverse)

Description

Search ClinGen dosage sensitivity curations by gene symbol. Returns haploinsufficiency (HI) and triplosensitivity (TS) scores (0-3 scale). Score 3 = Sufficient evidence for dosage pathogenicity. Critical for CNV interpretation. Example: MECP2 has HI score of 3.

Quick Install

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Installation

pip install tooluniverse

Status

Published

Reviewer

Automated import

Date Added

2026-03-30

Tags

tooluniverse clingen gene-disease clinical-genetics