DoseResponse calculate ic50

Description

Determine the half-maximal inhibitory or effective concentration (IC50/EC50) from paired concentration-response data by fitting the Hill sigmoidal equation. Requires a minimum of 4 data points that span the dynamic response range. Output includes EC50 with 95% confidence interval, Hill exponent n, top plateau Emax, bottom plateau Emin, R2 goodness-of-fit, and log10(EC50) for convenient pIC50 conversion. Suited to potency ranking in compound screens, structure-activity relationship analysis, a...

Quick Install

Installation

pip install tooluniverse

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