NCA fit one compartment

Description

Fit a one-compartment IV bolus pharmacokinetic model (C(t) = C0 × exp(-k_el × t)) to plasma concentration-time data using nonlinear least squares. Returns C0 (initial concentration), k_el (elimination rate constant), t½ (half-life), R², and when dose is provided: Vd (volume of distribution) and CL (clearance). Assumes mono-exponential decline — appropriate for drugs with rapid distribution and linear elimination. If R² < 0.85, consider a two-compartment model. Use NCA_compute_parameters for m...

Quick Install

Installation

pip install tooluniverse

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